Monthly Letter

1. Single-Cell Transcriptional Profiling of Aortic Endothelium Identifies a Hierarchy from Endovascular Progenitors to Differentiated Cells.
Lukowski SW, Patel J, Andersen SB, Sim SL, Wong HY, Tay J, Winkler I, Powell JE, Khosrotehrani K. Cell Rep. 2019 May 28;27(9):2748-2758.e3. doi: 10.1016/j.celrep.2019.04.102.

2. Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans.
Abe K, Cox A, Takamatsu N, Velez G, Laxer RM, Tse SML, Mahajan VB, Bassuk AG, Fuchs H, Ferguson PJ, Hrabe de Angelis M. Proc Natl Acad Sci U S A. 2019 May 28. pii: 201819825. doi: 10.1073/pnas.1819825116.

3. Benchmarking single cell RNA-sequencing analysis pipelines using mixture control experiments.
Tian L, Dong X, Freytag S, Lê Cao KA, Su S, JalalAbadi A, Amann-Zalcenstein D, Weber TS, Seidi A, Jabbari JS, Naik SH, Ritchie ME. Nat Methods. 2019 May 27. doi: 10.1038/s41592-019-0425-8.

4. Primary transcriptome and translatome analysis determines transcriptional and translational regulatory elements encoded in the Streptomyces clavuligerus genome.
Hwang S, Lee N, Jeong Y, Lee Y, Kim W, Cho S, Palsson BO, Cho BK. Nucleic Acids Res. 2019 May 27. pii: gkz471. doi: 10.1093/nar/gkz471.

5. Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation.
Cuitiño MC, Pécot T, Sun D, Kladney R, Okano-Uchida T, Shinde N, Saeed R, Perez-Castro AJ, Webb A, Liu T, Bae SI, Clijsters L, Selner N, Coppola V, Timmers C, Ostrowski MC, Pagano M, Leone G. Cell Rep. 2019 May 21. pii: S2211-1247(19)30608-4. doi: 10.1016/j.celrep.2019.05.004.

6. A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia.
Baryawno N, Przybylski D, Kowalczyk MS, Kfoury Y, Severe N, Gustafsson K, Kokkaliaris KD, Mercier F, Tabaka M, Hofree M, Dionne D, Papazian A, Lee D, Ashenberg O, Subramanian A, Vaishnav ED, Rozenblatt-Rosen O, Regev A, Scadden DT. Cell. 2019 May 9. pii: S0092-8674(19)30459-3. doi: 10.1016/j.cell.2019.04.040.

7. Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.
Clijsters L, Hoencamp C, Calis JJA, Marzio A, Handgraaf SM, Cuitino MC, Rosenberg BR, Leone G, Pagano M. Mol Cell. 2019 May 17. pii: S1097-2765(19)30280-1. doi: 10.1016/j.molcel.2019.04.010.

8. Cell-Type Heterogeneity in Adipose Tissue Is Associated with Complex Traits and Reveals Disease-Relevant Cell-Specific eQTLs.
Glastonbury CA, Couto Alves A, El-Sayed Moustafa JS, Small KS. Am J Hum Genet. 2019 May 22. pii: S0002-9297(19)30121-1. doi: 10.1016/j.ajhg.2019.03.025.

9. Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.
Clark BS, Stein-O'Brien GL, Shiau F, Cannon GH, Davis-Marcisak E, Sherman T, Santiago CP, Hoang TV, Rajaii F, James-Esposito RE, Gronostajski RM, Fertig EJ, Goff LA, Blackshaw S. Neuron. 2019 May 8. pii: S0896-6273(19)30345-9. doi: 10.1016/j.neuron.2019.04.010.

10. Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA.
Donadon I, Bussani E, Riccardi F, Licastro D, Romano G, Pianigiani G, Pinotti M, Kostantinova P, Evers M, Lin S, Rüegg MA, Pagani F. Nucleic Acids Res. 2019 May 25. pii: gkz469. doi: 10.1093/nar/gkz469.

11. Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.
Zhao J, Lee EE, Kim J, Yang R, Chamseddin B, Ni C, Gusho E, Xie Y, Chiang CM, Buszczak M, Zhan X, Laimins L, Wang RC. Nat Commun. 2019 May 24;10(1):2300. doi: 10.1038/s41467-019-10246-5.

12. Transcription Restart Establishes Chromatin Accessibility after DNA Replication.
Stewart-Morgan KR, Reverón-Gómez N, Groth A. Mol Cell. 2019 May 16. pii: S1097-2765(19)30352-1. doi: 10.1016/j.molcel.2019.04.033.

13. Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis.
Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW, Gan Z. Proc Natl Acad Sci U S A. 2019 May 23. pii: 201814480. doi: 10.1073/pnas.1814480116.

14. The C. elegans embryonic transcriptome with tissue, time, and alternative splicing resolution.
Warner AD, Gevirtzman L, Hillier LW, Ewing B, Waterston RH. Genome Res. 2019 May 23. doi: 10.1101/gr.243394.118.

15. Ribonucleoprotein capture by in vivo expression of a designer pentatricopeptide repeat protein in Arabidopsis.
McDermott JJ, Watkins KP, Williams-Carrier R, Barkan A. Plant Cell. 2019 May 23. pii: tpc.00177.2019. doi: 10.1105/tpc.19.00177.

16. Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.
Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A. Nat Commun. 2019 May 22;10(1):2266. doi: 10.1038/s41467-019-09769-8.

17. Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes.
Pizzolato G, Kaminski H, Tosolini M, Franchini DM, Pont F, Martins F, Valle C, Labourdette D, Cadot S, Quillet-Mary A, Poupot M, Laurent C, Ysebaert L, Meraviglia S, Dieli F, Merville P, Milpied P, Déchanet-Merville J, Fournié JJ. Proc Natl Acad Sci U S A. 2019 May 22. pii: 201818488. doi: 10.1073/pnas.1818488116.

18. An Atlas of Vagal Sensory Neurons and Their Molecular Specialization.
Kupari J, Häring M, Agirre E, Castelo-Branco G, Ernfors P. Cell Rep. 2019 May 21;27(8):2508-2523.e4. doi: 10.1016/j.celrep.2019.04.096.

19. The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21.
Schmidt K, Carroll JS, Yee E, Thomas DD, Wert-Lamas L, Neier SC, Sheynkman G, Ritz J, Novina CD. Cell Rep. 2019 May 21;27(8):2493-2507.e4. doi: 10.1016/j.celrep.2019.04.101.

20. Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming.
Fernandez-Perez A, Sathe AA, Bhakta M, Leggett K, Xing C, Munshi NV. Cell Rep. 2019 May 21;27(8):2354-2369.e7. doi: 10.1016/j.celrep.2019.04.077.

21. Diagnostic Utility of Exome Sequencing for Kidney Disease. Reply.
Groopman E, Goldstein D, Gharavi A. N Engl J Med. 2019 May 23;380(21):2080-2081. doi: 10.1056/NEJMc1903250.

22. Diagnostic Utility of Exome Sequencing for Kidney Disease.
Bleyer AJ, Kmoch S, Greka A. N Engl J Med. 2019 May 23;380(21):2080. doi: 10.1056/NEJMc1903250.

23. Diagnostic Utility of Exome Sequencing for Kidney Disease.
Doreille A, Raymond L, Mesnard L. N Engl J Med. 2019 May 23;380(21):2079-2080. doi: 10.1056/NEJMc1903250.

24. Diagnostic Utility of Exome Sequencing for Kidney Disease.
Schrezenmeier E, Budde K, Bergmann C. N Engl J Med. 2019 May 23;380(21):2078. doi: 10.1056/NEJMc1903250.

25. Diagnostic Utility of Exome Sequencing for Kidney Disease.
Carriazo S, Ortiz A, Perez-Gomez MV. N Engl J Med. 2019 May 23;380(21):2078. doi: 10.1056/NEJMc1903250.

26. sRNAbench and sRNAtoolbox 2019: intuitive fast small RNA profiling and differential expression.
Aparicio-Puerta E, Lebrón R, Rueda A, Gómez-Martín C, Giannoukakos S, Jaspez D, Medina JM, Zubkovic A, Jurak I, Fromm B, Marchal JA, Oliver J, Hackenberg M. Nucleic Acids Res. 2019 May 22. pii: gkz415. doi: 10.1093/nar/gkz415.

27. HOT or not: examining the basis of high-occupancy target regions.
Wreczycka K, Franke V, Uyar B, Wurmus R, Bulut S, Tursun B, Akalin A. Nucleic Acids Res. 2019 May 22. pii: gkz460. doi: 10.1093/nar/gkz460.

28. ChEA3: transcription factor enrichment analysis by orthogonal omics integration.
Keenan AB, Torre D, Lachmann A, Leong AK, Wojciechowicz ML, Utti V, Jagodnik KM, Kropiwnicki E, Wang Z, Ma'ayan A. Nucleic Acids Res. 2019 May 22. pii: gkz446. doi: 10.1093/nar/gkz446.

29. Geneshot: search engine for ranking genes from arbitrary text queries.
Lachmann A, Schilder BM, Wojciechowicz ML, Torre D, Kuleshov MV, Keenan AB, Ma'ayan A. Nucleic Acids Res. 2019 May 22. pii: gkz393. doi: 10.1093/nar/gkz393.

30. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis.
Tang Z, Kang B, Li C, Chen T, Zhang Z. Nucleic Acids Res. 2019 May 22. pii: gkz430. doi: 10.1093/nar/gkz430.

31. RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome.
Belbachir N, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo H, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S, Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Baró I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S. Eur Heart J. 2019 May 21. pii: ehz308. doi: 10.1093/eurheartj/ehz308.

32. RNA sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB.
Reinhold WC, Varma S, Sunshine M, Elloumi F, Ofori-Atta K, Lee S, Trepel JB, Meltzer PS, Doroshow JH, Pommier Y. Cancer Res. 2019 May 21. pii: canres.2047.2018. doi: 10.1158/0008-5472.CAN-18-2047.

33. Morpholinos Do Not Elicit an Innate Immune Response during Early Xenopus Embryogenesis.
Paraiso KD, Blitz IL, Zhou JJ, Cho KWY. Dev Cell. 2019 May 20;49(4):643-650.e3. doi: 10.1016/j.devcel.2019.04.019.

34. Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor.
He Z, Luo Y, Shang X, Sun JS, Carlson JR. PLoS Biol. 2019 May 21;17(5):e2006619. doi: 10.1371/journal.pbio.2006619. eCollection 2019 May.

35. Model-based understanding of single-cell CRISPR screening.
Duan B, Zhou C, Zhu C, Yu Y, Li G, Zhang S, Zhang C, Ye X, Ma H, Qu S, Zhang Z, Wang P, Sun S, Liu Q. Nat Commun. 2019 May 20;10(1):2233. doi: 10.1038/s41467-019-10216-x.

36. Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis.
Shen WC, Lai YC, Li LH, Liao K, Lai HC, Kao SY, Wang J, Chuong CM, Hung SC. Nat Commun. 2019 May 20;10(1):2226. doi: 10.1038/s41467-019-10197-x.

37. MutationDistiller: user-driven identification of pathogenic DNA variants.
Hombach D, Schuelke M, Knierim E, Ehmke N, Schwarz JM, Fischer-Zirnsak B, Seelow D. Nucleic Acids Res. 2019 May 20. pii: gkz330. doi: 10.1093/nar/gkz330.

38. A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy.
Helbig I, Lopez-Hernandez T, Shor O, Galer P, Ganesan S, Pendziwiat M, Rademacher A, Ellis CA, Hümpfer N, Schwarz N, Seiffert S, Peeden J, Shen J, Štěrbová K, Hammer TB, Møller RS, Shinde DN, Tang S, Smith L, Poduri A, Krause R, Benninger F, Helbig KL, Haucke V, Weber YG; EuroEPINOMICS-RES Consortium; GRIN Consortium. Am J Hum Genet. 2019 May 2. pii: S0002-9297(19)30147-8. doi: 10.1016/j.ajhg.2019.04.001.

39. MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing.
Keren-Shaul H, Kenigsberg E, Jaitin DA, David E, Paul F, Tanay A, Amit I. Nat Protoc. 2019 May 17. doi: 10.1038/s41596-019-0164-4.

40. miR-450a acts as a tumor suppressor in ovarian cancer by regulating energy metabolism.
Muys BR, Sousa JF, Plaça JR, Araújo LF, Sarshad AA, Anastasakis DG, Wang X, Li XL, de Molfetta GA, Ramão A, Lal A, Vidal DO, Hafner M, Silva WA. Cancer Res. 2019 May 17. pii: canres.0490.2019. doi: 10.1158/0008-5472.CAN-19-0490.

41. LncRNA SNHG10 facilitates hepatocarcinogenesis and metastasis by modulating its homolog SCARNA13 via a positive feedback loop.
Lan T, Yuan K, Yan X, Xu L, Liao H, Hao X, Wang J, Liu H, Xie K, Li J, Liao M, Huang J, Zeng Y, Wu H. Cancer Res. 2019 May 17. pii: canres.4044.2018. doi: 10.1158/0008-5472.CAN-18-4044.

42. Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma.
Wu X, Stenson M, Abeykoon J, Nowakowski KE, Zhang L, Lawson J, Wellik L, Li Y, Krull J, Wenzl K, Novak AJ, Ansell S, Bishop G, Billadeau DD, Peng KW, Giles F, Schmitt DM, Witzig TE. Blood. 2019 May 17. pii: blood.2018874560. doi: 10.1182/blood.2018874560.

43. Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons.
Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, Paquola A, Lee H, Mertens J, Gage FH. Elife. 2019 May 17;8. pii: e41356. doi: 10.7554/eLife.41356.

44. Hydro-Seq enables contamination-free high-throughput single-cell RNA-sequencing for circulating tumor cells.
Cheng YH, Chen YC, Lin E, Brien R, Jung S, Chen YT, Lee W, Hao Z, Sahoo S, Min Kang H, Cong J, Burness M, Nagrath S, S Wicha M, Yoon E. Nat Commun. 2019 May 15;10(1):2163. doi: 10.1038/s41467-019-10122-2.

45. High-Throughput Single-Cell Transcriptome Profiling of Plant Cell Types.
Shulse CN, Cole BJ, Ciobanu D, Lin J, Yoshinaga Y, Gouran M, Turco GM, Zhu Y, O'Malley RC, Brady SM, Dickel DE. Cell Rep. 2019 May 14;27(7):2241-2247.e4. doi: 10.1016/j.celrep.2019.04.054.

46. Clonal Vγ6+Vδ4+ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection.
Marchitto MC, Dillen CA, Liu H, Miller RJ, Archer NK, Ortines RV, Alphonse MP, Marusina AI, Merleev AA, Wang Y, Pinsker BL, Byrd AS, Brown ID, Ravipati A, Zhang E, Cai SS, Limjunyawong N, Dong X, Yeaman MR, Simon SI, Shen W, Durum SK, O'Brien RL, Maverakis E, Miller LS. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10917-10926. doi: 10.1073/pnas.1818256116. Epub 2019 May 14.

47. Leptin in hippocampus mediates benefits of mild exercise by an antioxidant on neurogenesis and memory.
Yook JS, Rakwal R, Shibato J, Takahashi K, Koizumi H, Shima T, Ikemoto MJ, Oharomari LK, McEwen BS, Soya H. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10988-10993. doi: 10.1073/pnas.1815197116. Epub 2019 May 13.

48. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis.
Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA. Gastroenterology. 2019 May 8. pii: S0016-5085(19)40858-5. doi: 10.1053/j.gastro.2019.05.002.

49. Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.
McDonald PC, Chafe SC, Brown WS, Saberi S, Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA, Karasinska JM, Kalloger SE, Supuran CT, Schaeffer DF, Bashashati A, Shah SP, Topham JT, Yapp DT, Li J, Renouf DJ, Stanger BZ, Dedhar S. Gastroenterology. 2019 May 9. pii: S0016-5085(19)40862-7. doi: 10.1053/j.gastro.2019.05.004.

50. Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallée VP, Lemieux S, Gendron P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hébert J, Sauvageau G, Zaugg J, Barabé F, Pabst C. Blood. 2019 May 10. pii: blood.2018862383. doi: 10.1182/blood.2018862383.

51. The RNA workbench 2.0: next generation RNA data analysis.
Fallmann J, Videm P, Bagnacani A, Batut B, Doyle MA, Klingstrom T, Eggenhofer F, Stadler PF, Backofen R, Grüning B. Nucleic Acids Res. 2019 May 10. pii: gkz353. doi: 10.1093/nar/gkz353.

52. Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids.
Kim S, Lowe A, Dharmat R, Lee S, Owen LA, Wang J, Shakoor A, Li Y, Morgan DJ, Hejazi AA, Cvekl A, DeAngelis MM, Zhou ZJ, Chen R, Liu W. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10824-10833. doi: 10.1073/pnas.1901572116. Epub 2019 May 9.

53. modEnrichr: a suite of gene set enrichment analysis tools for model organisms.
Kuleshov MV, Diaz JEL, Flamholz ZN, Keenan AB, Lachmann A, Wojciechowicz ML, Cagan RL, Ma'ayan A. Nucleic Acids Res. 2019 May 9. pii: gkz347. doi: 10.1093/nar/gkz347.

54. Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells.
Ma L, Pak ML, Ou J, Yu J, St Louis P, Shan Y, Hutchinson L, Li S, Brehm MA, Zhu LJ, Green MR. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10482-10487. doi: 10.1073/pnas.1903550116. Epub 2019 May 8.

55. CPGAVAS2, an integrated plastome sequence annotator and analyzer.
Shi L, Chen H, Jiang M, Wang L, Wu X, Huang L, Liu C. Nucleic Acids Res. 2019 May 8. pii: gkz345. doi: 10.1093/nar/gkz345.

56. Mutational Landscape of the Transcriptome Offers Putative Targets for Immunotherapy of Myeloproliferative Neoplasms.
Schischlik F, Jäger R, Rosebrock F, Hug E, Schuster MK, Holly R, Fuchs E, Milosevic Feenstra JD, Bogner E, Gisslinger B, Schalling M, Rumi E, Pietra D, Fischer GF, Faé I, Vulliard L, Menche J, Haferlach T, Meggendorfer M, Stengel A, Bock C, Cazzola M, Gisslinger H, Kralovics R. Blood. 2019 May 7. pii: blood.2019000519. doi: 10.1182/blood.2019000519.

57. Hydroa vacciniforme-like lymphoproliferative disorder: an EBV disease with a low risk of systemic illness in Caucasians.
Cohen JI, Manoli I, Dowdell KC, Krogmann TA, Tamura D, Radecki P, Bu W, Turk SP, Liepshutz K, Hornung RL, Fassihi H, Sarkany RP FRCP, Bonnycastle LL, Chines PS, Swift AJ, Myers TG, Levoska MA, DiGiovanna JJ, Collins FS, Kraemer KH, Pittaluga S, Jaffe ES. Blood. 2019 May 7. pii: blood.2018893750. doi: 10.1182/blood.2018893750.

58. Mucin O-glycan microarrays.
Li Z, Chai W. Curr Opin Struct Biol. 2019 May 4;56:187-197. doi: 10.1016/j.sbi.2019.03.032.

59. Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response.
Caruso S, Calatayud AL, Pilet J, La Bella T, Rekik S, Imbeaud S, Letouzé E, Meunier L, Bayard Q, Rohr-Udilova N, Péneau C, Grasl-Kraupp B, de Koning L, Ouine B, Bioulac-Sage P, Couchy G, Calderaro J, Nault JC, Zucman-Rossi J, Rebouissou S. Gastroenterology. 2019 May 4. pii: S0016-5085(19)36771-X. doi: 10.1053/j.gastro.2019.05.001.

60. The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription.
Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J. Nat Commun. 2019 May 6;10(1):2071. doi: 10.1038/s41467-019-10102-6.

61. Efficient integration of heterogeneous single-cell transcriptomes using Scanorama.
Hie B, Bryson B, Berger B. Nat Biotechnol. 2019 May 6. doi: 10.1038/s41587-019-0113-3.

62. SCRABBLE: single-cell RNA-seq imputation constrained by bulk RNA-seq data.
Peng T, Zhu Q, Yin P, Tan K. Genome Biol. 2019 May 6;20(1):88. doi: 10.1186/s13059-019-1681-8.

63. Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma.
Christensen E, Birkenkamp-Demtröder K, Sethi H, Shchegrova S, Salari R, Nordentoft I, Wu HT, Knudsen M, Lamy P, Lindskrog SV, Taber A, Balcioglu M, Vang S, Assaf Z, Sharma S, Tin AS, Srinivasan R, Hafez D, Reinert T, Navarro S, Olson A, Ram R, Dashner S, Rabinowitz M, Billings P, Sigurjonsson S, Andersen CL, Swenerton R, Aleshin A, Zimmermann B, Agerbæk M, Lin CJ, Jensen JB, Dyrskjøt L. J Clin Oncol. 2019 May 6:JCO1802052. doi: 10.1200/JCO.18.02052.

64. In silico analysis of RNA-seq requires a more complete description of methodology.
Simoneau J, Scott MS. Nat Rev Mol Cell Biol. 2019 May 3. doi: 10.1038/s41580-019-0137-z.

65. High-resolution, strand-specific R-loop mapping via S9.6-based DNA-RNA immunoprecipitation and high-throughput sequencing.
Sanz LA, Chédin F. Nat Protoc. 2019 May 3. doi: 10.1038/s41596-019-0159-1.

66. Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p.
Wu P, Cai J, Chen Q, Han B, Meng X, Li Y, Li Z, Wang R, Lin L, Duan C, Kang C, Jiang C. Nat Commun. 2019 May 3;10(1):2045. doi: 10.1038/s41467-019-10025-2.

67. Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma.
Giraldez MD, Spengler RM, Etheridge A, Goicochea AJ, Tuck M, Choi SW, Galas DJ, Tewari M. EMBO J. 2019 May 3. pii: e101695. doi: 10.15252/embj.2019101695.

68. Absolute quantification of translational regulation and burden using combined sequencing approaches.
Gorochowski TE, Chelysheva I, Eriksen M, Nair P, Pedersen S, Ignatova Z. Mol Syst Biol. 2019 May 3;15(5):e8719. doi: 10.15252/msb.20188719.

69. Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation.
Cocciardi S, Dolnik A, Kapp-Schwoerer S, Rücker FG, Lux S, Blätte TJ, Skambraks S, Krönke J, Heidel FH, Schnöder TM, Corbacioglu A, Gaidzik VI, Paschka P, Teleanu V, Göhring G, Thol F, Heuser M, Ganser A, Weber D, Sträng E, Kestler HA, Döhner H, Bullinger L, Döhner K. Nat Commun. 2019 May 2;10(1):2031. doi: 10.1038/s41467-019-09745-2.

70. A multigene assay determines risk of recurrence in patients with triple-negative breast cancer.
Stewart RL, Updike KL, Factor RE, Henry NL, Boucher KM, Bernard PS, Varley KE. Cancer Res. 2019 May 2. pii: canres.3014.2018. doi: 10.1158/0008-5472.CAN-18-3014.

71. Clinical application of next-generation sequencing to the practice of neurology.
Rexach J, Lee H, Martinez-Agosto JA, Németh AH, Fogel BL. Lancet Neurol. 2019 May;18(5):492-503. doi: 10.1016/S1474-4422(19)30033-X. Review.

72. Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity.
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73. HIF-1α regulates IL-1β and IL-17 in sarcoidosis.
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